Overexpression of quality control proteins reduces prion conversion in prion-infected cells
نویسندگان
چکیده
منابع مشابه
D-Leucine Suppresses Prion Formation in Prion-Infected Culture Cells
C l i n M e d International Library Citation: Miyashita K, Suzuki M, Nishijima K, Hachiya N (2014) D-Leucine Suppresses Prion Formation in Prion-Infected Culture Cells. Int J Neurol Neurother 1:011 Received: September 20, 2014: Accepted: November 20, 2014: Published: November 24, 2014 Copyright: © 2014 Miyashita K. This is an open-access article distributed under the terms of the Creative Commo...
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Prion diseases are fatal neurodegenerative disorders and no effective treatment has been established to date. In this study, we evaluated the effect of FK506 (tacrolimus), a macrolide that is known to be a mild immunosuppressant, on prion infection, using cell culture and animal models. We found that FK506 markedly reduced the abnormal form of prion protein (PRNP(Sc)) in the cell cultures (N2a5...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.ra118.002754